CRISPR Platform Scans DNA to Predict Off-Target Effects

06:40 EDT 30 Jun 2017 | Genetic Engineering News

If you’re reworking a genome, you might want to heed the old saying, “Measure twice, cut once.” Otherwise, your attempts to right the genome or modify it for special purposes could end in genomic wrongs—off-target effects. For example, the popular gene-editing tool known as CRISPR could go astray, altering genes other than the ones it was meant to alter. If only CRISPR’s potential slips could be foreseen! Then, perhaps, they could be avoided, and CRISPR would realize its potential not only in research, but also in medicine. Scientists from The University of Texas at Austin took an important step toward safer gene-editing cures for life-threatening disorders, from cancer to HIV to Huntington's disease, by developing CHAMP, which stands for chip-hybridized association-mapping platform. It repurposes next-generation sequencing chips to enable the massively parallel profiling of protein-nucleic acid interactions. The scientists used CHAMP to provide the first comprehensive survey ...

Original Article: CRISPR Platform Scans DNA to Predict Off-Target Effects


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