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Hypertension is a condition characterized by persistent high arterial blood pressure. Hypertension may have no known cause (essential or idiopathic hypertension) or may be associated with other primary diseases (secondary hypertension), and is considered a risk factor for the development of heart disease, peripheral vascular disease, stroke, and kidney disease. Preeclampsia is a similar condition that occurs in 5-10% of all pregnancies (most common in first time pregnancies) and is characterized by high blood pressure, edema, and protein in the urine. Complications of preeclampsia include eclampsia (convulsions and coma) and intrauterine fetal demise.
Researchers at the National Institute on Aging (NIA) have developed monoclonal antibodies and antigen binding fragments that specifically bind marinobufagenin, a steroid that, in abundance, can exacerbate pathological states associated with fluid retention, including essential and salt-sensitive hypertension, preeclampsia, and uremic cardiomyopathy. Thus, marinobufagenin may be an appropriate target in the treatment of these disorders. In addition, NIA researchers developed methods of diagnosing hypertensive disorders, e.g., by detecting the binding of antibodies against marinobufagenin in a patient sample.
The National Institute on Aging, Laboratory of Cardiovascular Science, seeks licensing partners and statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize these antibodies.
The United States Food and Drug Administration (FDA) has approved on October 8th 2013 Adempas® (riociguat) tablets for: (i) the treatment of adults with persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) (WHO* Group 4) after ...
Cardiology is a specialty of internal medicine. Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...