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The receptor for advanced glycation end products (RAGE) is a protein implicated in the development of vascular hyperplasia and in atherogenesis. RAGE is a cell surface protein that triggers signaling pathways leading to inflammation and RAGE-stimulated inflammation can contribute to adverse inflammatory conditions, such as atherosclerosis and arterial restenosis (a serious pathological complication that can follow surgical cardiovascular interventions like angioplasty).
Researchers at the National Institute on Aging (NIA) have developed methods to produce a soluble receptor for advanced glycation end products (sRAGE) in mammalian cells and the use of sRAGE for the treatment of vascular diseases and disorders, given that sRAGE has mammalian post-translational modifications. Further, sRAGE has been used to treat arterial restenosis and atherosclerosis in animal models. sRAGE, is used as a therapeutic agent that is believed to act as a decoy to diminish RAGE-dependent signaling, thereby attenuating inflammation and pathogenic consequences. sRAGE also has been associated with anti-mitotic effects.
The National Institute on Aging, Laboratory of Cardiovascular Science, seeks licensing partners and statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize sRAGE.
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...
Vascular relates to blood vessels (Oxford Medical Dictionary) and can be used to describe the supply of blood, a disease affecting the blood vessels or molecules associated with these structures. For example, <!--LGfEGNT2Lhm-->atherosclerosis ...