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Polymer matrix-based sustained-release formulations have gained significant interest in recent years for both parenteral and delivery of small molecules as well as proteins and other biological molecules. Compared to conventional dosage forms, these delivery systems offer improved efficacy, reduced toxicity, convenience and improved patient compliance. Colloidal carriers such as microparticles are considered a promising approach for targeting drugs to specific organs that could permit the sustained release at the target site and reduce potential side effects.
Matrix-structured microparticles that are formed by coacervation are desirable since they permit therapeutic agents to become incorporated into the microparticles under mild conditions (e.g. delivery of nucleic acids).
Researchers at the National Institute on Aging (NIA) have discovered novel microparticles that are formed using a coacervation process, methods of forming the microparticles (with enhanced efficiency for microparticle sustained release compositions), and methods of using the microparticles for the sustained release administration of therapeutic agents (coacervate microparticles can be standardized and employed for the delivery of a variety of therapeutic agents).
Researchers at the NIA seek licensing and/or co-development research collaborations.
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...