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Researchers identify novel mechanism underlying efficacy of common heart failure drug

12:20 EDT 3 Jul 2017 | Medical Xpress

Beta-blocker drugs serve a key role in the treatment of heart failure, preventing bombardment of the heart by catecholamines - substances like epinephrine and norepinephrine - which overexcite and stress the heart. But not all heart failure patients respond to beta-blockers, for reasons that have been unclear. Now, in new work, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) show that dysfunction of beta-adrenergic receptor 3 (β3AR) - a novel beta-blocker target - and consequent decreases in a critical cardioprotective phospholipid may be to blame.

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