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Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis

19:18 EDT 3 Jul 2017 | Nature Publishing

Structural analysis of the uridyl transferases TUT4 and TUT7 reveals the use of two functional modules in the switch from monouridylation of pre-let-7, which promotes let-7 expression, to oligouridylation of pre-let-7, which marks it for degradation.

Original Article: Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis

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