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Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

19:18 EDT 3 Jul 2017 | Nature Publishing

Asparagine endopeptidase (AEP) cleaves human α-synuclein at Asn103, yielding a fragment with higher aggregation propensity than that of the full-length protein. Truncated α-synuclein is also more neurotoxic and leads to dopaminergic neuronal loss and motor impairments in mice.

Original Article: Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

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