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c-MYC mRNA tail tale about glutamine control of transcription

22:11 EDT 3 Jul 2017 | Nature Publishing

Dejure et al (2017) demonstrates an intriguing link between glutamine, c-MYC protein levels, and c-MYC-dependent transcription. Glutamine-dependent c-MYC protein level, which is sensed through the c-MYC mRNA 3'-UTR, determines global transcriptional response to glutamine deprivation in HCT116 colon cancer cells. These findings add another layer of complexity to c-MYC's role as a nexus in metabolic regulation.

Original Article: c-MYC mRNA tail tale about glutamine control of transcription

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