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Small-molecule therapeutic boosts spatial memory and motor function in Rett syndrome mice

20:00 EDT 4 Jul 2017 | AAAS

(The Company of Biologists) Rett syndrome is a neurological disorder affecting learning and development, caused by a mutation in the MECP2 gene triggering decreased levels of brain-derived neurotrophic factor (BDNF). Previous research has shown that treatment with a small-molecule BDNF mimetic, LM22A-4, can lead to improvements in respiratory problems associated with the disease. Now, new research reveals that LM22A-4 may also improve spatial memory and motor skill defects in a Rett syndrome mouse model.

Original Article: Small-molecule therapeutic boosts spatial memory and motor function in Rett syndrome mice

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