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(University of Oxford) Sequencing the genome of the sand rat, a desert rodent susceptible to nutritionally induced diabetes, revealed an unusual chromosome region skewed toward G and C nucleotides. This region includes the Pdx1 homeobox gene, a transcriptional activator of insulin, which has undergone massive sequence change, likely contributing to diabetes and adaptation to low caloric intake, implying that mutation rate varies within a genome and that hotspots of high mutation rate may influence ecological adaptation and constraint.
Original Article: Genome sequence of a diabetes-prone rodentNEXT ARTICLE
DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule. During DNA sequencing, the bases of a small fragment of DNA are sequentially identified from signals emitted as each fragment is re-synthesized from a ...
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...