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New chemical synthesis method can produce an exciting range of novel compounds

20:00 EDT 3 Jul 2017 | AAAS

(Nagoya Institute of Technology) Researchers at Nagoya Institute of Technology have established a reaction catalyzed by Bis(imidazoline)/zinc whereby 2H-azirines react with phosphite, yielding aziridines at a high enantiomeric ratio. Given the value of existing aziridines as chemical building blocks as well as medications such as the chemotherapy agent mitomycin C and the antibiotics azicemicins, this reaction system could provide a range of new targets with pharmaceutical potential.

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