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Amgen Licenses Ligand's Captisol Technology for AML Candidate AMG 330

05:41 EDT 18 Jul 2017 | Genetic Engineering News

Amgen has licensed Ligand Pharmaceuticals’ Captisol ® technology for use in the formulation of AMG 330, the biotech giant’s Phase I acute myeloid leukemia candidate, through an agreement whose value was not disclosed. The companies have inked a commercial license and supply agreement that replaces an earlier research agreement that allowed Amgen to evaluate AMG 330 with Captisol in preclinical and early clinical studies. The new agreement gives Amgen exclusive worldwide rights to combine Captisol with AMG 330 in human drugs for a variety of therapeutic indications, Ligand said. AMG 330 is an anti-CD33 x anti-CD3 Bispecific T cell Engager (BiTE ® ) antibody construct. Captisol is a patent-protected, chemically modified cyclodextrin whose structure is designed to optimize the solubility and stability of drugs. “This agreement expands our license relationship with Amgen on AMG 330,” Ligand CEO John Higgins said in a statement issued yesterday. “Ligand’s ...

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