The regulation of immune tolerance by FOXP3

01:52 EDT 31 Jul 2017 | Nature Publishing

This Review considers how forkhead box protein P3 (FOXP3) — the key transcription factor of regulatory T (Treg) cells — is regulated both at the transcriptional level and through post-translational modifications. The authors explain how FOXP3 interacts with other molecules to induce and maintain Treg cell populations, and they discuss the potential of therapeutically targeting FOXP3 in the context of human disease.

Original Article: The regulation of immune tolerance by FOXP3


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