Local epigenetic reprogramming induced by G-quadruplex ligands

03:29 EDT 1 Aug 2017 | Nature Publishing

Delayed resolution of G-quadruplexes during replication can induce localized loss of epigenetic information and changes in gene expression. Now, this effect has been used to discover biologically potent G-quadruplex ligands and to demonstrate that G-quadruplex stabilization can induce epigenetic changes that are heritable across cell divisions even after the ligand is removed.

Original Article: Local epigenetic reprogramming induced by G-quadruplex ligands


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