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Protein misfolding disorders (PMDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), are characterized by the accumulation of misfolded protein aggregates in tissues including the brain. A few rare PMDs, such as bovine spongiform encephalopathy (BSE, or mad cow disease), and Creutzfeldt-Jacob Disease (CJD), can even be transmitted between humans or from animals to humans. In these cases exposure to the causative misfolded protein aggregates, known as prions, triggers the transformation of normal proteins into the abnormal form. Effectively, prions ‘seed’ the development of misfolded protein aggregation in the brain of the recipient, and this leads to the accumulation of toxic substances that destroy neurons. Protein aggregation isn’t limited to the widely recognized PMDs, however. About 90% of patients with type 2 diabetes (T2D) develop pancreatic islet deposits of the peptide hormone islet amyloid polypeptide (IAPP). These misfolded protein aggregates start accumulating many ...
Original Article: Transmission of Diabetes Prion-Like Aggregates Triggers Disease SymptomsNEXT ARTICLE
Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...
Parkinson's is a progressive neurological condition, affecting one person in every 500, 95% of which are over 40. It is caused by degeneration of more than 70% of the substantia nigra, which depletes the dopamine (the neurotransmitter involved in pro...