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A new report in the Journal of Leukocyte Biology describes an important step toward developing cancer treatments involving the body's immune system. Specifically, chimeric antigen receptor T cell (CAR-T) therapy involves collecting white blood cells from patients and re-engineering them into potent cancer-killing agents. This report showed that CAR-T cells from geriatric donors have specific defects that lead to decreased tumor cell-killing performance, when compared to younger donors. The study also uncovered the Geri-T method, which increases α5β1 integrin expression to reverse age-related CAR-T dysfunction.NEXT ARTICLE
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells. In vertebrates, it is composed of blo...