A Braf kinase-inactive mutant induces lung adenocarcinoma

20:00 EDT 1 Aug 2017 | AAAS

(Centro Nacional de Investigaciones Oncológicas (CNIO)) The initiating oncogenic event in half of human lung adenocarcinomas is still unknown, a fact that complicates the development of selective targeted therapies. Researchers at the CNIO have demonstrated that the expression of an endogenous Braf kinase-inactive isoform in mice triggers lung adenocarcinoma in vivo, indicating that BRAF-inactivating mutations are initiating events in lung oncogenesis. The paper indicates that the signal intensity of the MAPK pathway is a critical determinant in tumor development.

Original Article: A Braf kinase-inactive mutant induces lung adenocarcinoma


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