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The use of gene-regulating microRNAs (miRNAs) for treating cancer is a promising concept, but in practice the approach has been hobbled by a lack of efficient delivery vehicles. miRNAs are subject to enzyme attack in the bloodstream, so traditional delivery approaches have involved packaging the short RNA strands in protective particles such as lipid-encapsulated nanoparticles. Unfortunately, such delivery vehicles can be toxic, or are too big to efficiently penetrate the tumor microenvironment. A team of researchers at Purdue University has now developed an miRNA delivery technique that does away with protective delivery vehicles completely. Instead, the approach couples a ‘naked’ miRNA molecule to folate (vitamin B9), to create a FolamiR conjugate that targets the folate receptor, which is overexpressed on many types of solid and hematologic cancers, but is expressed at insignificant levels on normal cells. In today’s Science Translational Medicine , Purdue University’s Andrea L. Kasinski ...
Original Article: Anticancer miRNA Coupled to Folate Needs No Protective PackagingNEXT ARTICLE
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...
Enzymes are proteins that catalyze (i.e., increase the rates of) chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical re...