Novel Botulinum Neurotoxin May Treat Range of Medical Disorders

04:55 EDT 3 Aug 2017 | Genetic Engineering News

Scientists at Stockholm University say their discovery of  new Botulinum neurotoxin type X (BoNT/X) could lead to a new class of therapeutics related to intracellular membrane trafficking and secretion. Currently, Botulinum toxins are used to treat over 80 medical conditions, including muscle spasms, overactive bladder, chronic migraine, cervical dystonia, sweating and cerebral palsy. The researchers published their study ("Identification and characterization of a novel botulinum neurotoxin") in Nature Communications. “BoNT/X is a novel BoNT with a unique substrate profile,” write the investigators.” Its discovery…provides a novel tool for studying intracellular membrane trafficking and presents a new potential therapeutic toxin for modulating secretions in cells.” "The discovery of BoNT/X facilitates the development of diagnostics and countermeasures which is important if someone would be exposed to a toxic amount of the substance,", says Pal Stenmark, Ph.D., associate professor, department of biochemistry and biophysics, adding that the  research team ...

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