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The accumulation of extracellular plaque is not the only neuropathological manifestation of Alzheimer’s disease. The degenerative condition is also marked by axonal swelling, which is caused by the intracellular accumulation of lysosomes. It is not clear, however, how axons, the parts of neurons that conduct electric impulses, come to be packed with lysosomes. Neither is it clear how lysosome accumulation may be related to disease. Both of these questions, however, are a little less puzzling now that Yale University researchers have completed a study on lysosome transport. The researchers explored the possibility is that lysosomes promote plaque buildup, the aggregation of β-amyloid (Aβ) fragments, because some of the enzymes that generate Aβ by cleaving a protein called amyloid precursor protein (APP) accumulate in the swellings with the immature lysosomes. When the researchers worked with a mouse model of impeded lysosome transport, they found that neurons that lacked ...
Original Article: Alzheimer’s Linked to Flaw in Lysosome TransportNEXT ARTICLE
Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase 'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...