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A team led by researchers at the Milner Center for Evolution at the University of Bath report that sequencing the DNA of the MRSA bacterium ( Staphylococcus aureus) can help identify patients most at risk of death and may lead to the development of new therapies. Their study (“Clonal differences in Staphylococcus aureus bacteraemia-associated mortality”) appears in Nature Microbiology . “…we phenotyped a collection of sequenced clinical S. aureus isolates from [about 300] patients with bloodstream infections, representing two globally important clonal types, CC22 and CC30,” write the investigators. “By adopting a genome-wide association study approach we identified and functionally verified several genetic loci that affect the expression of cytolytic toxicity and biofilm formation. By analyzing the pooled data comprising bacterial genotype and phenotype together with clinical metadata within a machine-learning framework, we found significant clonal differences in the determinants most predictive of poor infection outcome.” ...
Original Article: Genotyping MRSA Identifies Patients Most at Risk of DeathNEXT ARTICLE
DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule. During DNA sequencing, the bases of a small fragment of DNA are sequentially identified from signals emitted as each fragment is re-synthesized from a ...
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...
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