Non-Stick Chip Developed as Rapid, Portable Point-of-Care Test to Rival ELISA

06:42 EDT 8 Aug 2017 | Genetic Engineering News

Enzyme-linked immunosorbent assays (ELISAs) represent the gold standard for quantitatively detecting protein biomarkers and are used for applications such as diagnosing or monitoring disease, developing therapeutic approaches, tracking patients’ responses to treatment, and evaluating patients for clinical trials. But ELISAs are not particularly user friendly. The tests are time consuming and resource intensive and require trained personnel or automated liquid-handling robots, together with bulky data analysis equipment. ELISAs may also require multiple blocking and washing steps to prevent unwanted binding by nonspecific proteins that create background noise and reduce sensitivity. All these factors hold back the use of ELISAs in limited-resource settings and can delay results reaching clinicians who might be waiting to make life-saving decisions on treatment, reports a team of researchers at Duke University, Durham, NC. The Duke team, headed by Ashutosh Chilkoti, Ph.D., Daniel Y. Joh, and Angus M. Hucknall, Ph.D., has now developed a ...

Original Article: Non-Stick Chip Developed as Rapid, Portable Point-of-Care Test to Rival ELISA


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