Breast Cancer: KOL Insight [2017]

12:51 EDT 8 Aug 2017 | PR Newswire

LONDON, Aug.8, 2017 /PRNewswire/ -- How is Ibrance faring? Is Kisqali expected to be a threat?

Having dominated the HER2-positive breast cancer space for many years, Roche's blockbuster drug Herceptin is likely to face the threat of biosimilar trastuzumab in the coming years; KOLs weigh in on how biosimilar trastuzumab may be accepted by physicians and patients, its potential usage in different settings, as well as its chances to become the preferred agent in the HER2-positive space. Meanwhile, KOLs discuss how Roche's Perjeta is setting itself up for expanded use. Experts also give their views on how Pfizer's Ibrance is faring in the HER2-negative/HR-positive space and what challenges lie ahead for this drug, including the arrival of Novartis' Kisqali and Eli Lilly's abemaciclib. The potential usage of PARP inhibitors and PD-1/PD-L1 checkpoint inhibitors in triple-negative breast cancer is also explored. Twelve US and EU KOLs offer their candid insights on these issues and more.

In this 6 US and six EU KOLs offer their candid insights on 6 marketed therapies and 12 pipeline drugs.

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The table of contents >
The key business questions answered >
The key KOL quotes >
See the therapies covered >
Find out who the 6 EU & 6 US KOLs are >
Review an extract from the report - 1 drug profile >

Top Takeaways

Several biosimilar trastuzumab versions are under regulatory review. How do KOLs view these products and how do they envisage their future use?
Perjeta is under investigation as an adjuvant therapy for HER2-positive disease. What impact will the APHINITY study results have?
Neratinib is awaiting approval in the extended adjuvant setting. How do KOLs view this agent and is uptake likely to be significant?
What are Ibrance's chances of approval in other settings? And can Pfizer fend off competition from Kisqali and abemaciclib?
How do the alpha specific PI3 kinase inhibitors, alpelisib and taselisib shape up against the CDK4/6 inhibitors? KOLs offer their views on these agents and how they could be positioned.
Kisqali has received US approval for HER2-negative/HR-positive breast cancer. What benefits does this product need to show in order to compete effectively?
KOLs discuss how PARP inhibitors and checkpoint inhibitors may be used in triple-negative breast cancer (TNBC). What are KOLs' thoughts on these agents and how do they envisage TNBC to be treated in the future?


"Alpelisib is clearly more selective or alpha specific. This should allow for better targeting but we'll see if that pans out clinically. I think we need to be careful with the toxicity of these drugs."EU Key Opinion Leader

"There are still studies that need to be completed to address the issue of sequencing of different therapies. The bulk of the evidence does support first-line use with a CDK4/6 inhibitor, but then after you get beyond first-line therapy, it starts to become a bit more confusing." US Key Opinion Leader

Sample of therapies covered

Marketed Therapies

Herceptin (trastuzumab; Roche)
Kadcyla (ado-trastuzumab emtansine; Roche)
Perjeta (pertuzumab; Roche)
Tykerb/Tyverb (lapatinib; Novartis)
Plus 2 more - download the full list now >

Phase III

neratinib (PB 272; Puma Biotechnology)
margetuximab (MGAH 22; MacroGenics)
Gilotrif/Giotrif (afatinib; Boehringer Ingelheim)
Kisqali (ribociclib; Novartis)
Plus 8 more - download the full list now >

Sample of KOLs interviewed

KOLs from North America

Dr. Charles L. Vogel, MD. Professor of Clinical Medicine, Division of Haematology/Oncology, Miller School of Medicine, University of Miami, Florida.
Dr. Adam M. Brufsky, MD, PhD. Professor of Medicine at the University of Pittsburgh School of Medicine, Pittsburgh, PA.
Dr. Joyce O'Shaughnessy, MD. Specialises in medical oncology with board certification in both internal medicine and medical oncology. She is a Diplomate of the American Board of Internal Medicine, with subspecialty certification in medical oncology.

KOLs from Europe

Dr. Thomas Bachelot, MD. Head of the Breast Cancer Unit and the Clinical Trial Unit at the Centre Leon Berard, Lyon, France.
Dr. Adrian L. Harris, MD, DPhil. Professor of Medical Oncology at the University of Oxford and Director of the Cancer Research UK Medical Oncology Unit, London, England.
Dr. Ahmad Awada, MD. Head of Medical Oncology Clinic at Jules Bordet Cancer Institute, Brussels, Belgium.

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