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A newly discovered pain-processing pathway could lead to alternative treatments for chronic pain. The new treatments could even make use of existing cancer drugs that block the epidermal growth factor receptor (EGFR). This receptor, long a target in cancer therapies, has only recently received attention for its therapeutic potential against pain. A recent study implicating EGFR in pain processing found that this receptor and its natural ligand, epiregulin (EREG), interact to heighten pain perception. This finding, derived from experiments with mouse models, suggests that both EGFR and EREG could be suitable therapeutic targets for chronic pain in humans. Even if existing drugs that interfere with EGFR/EREG interactions were to fail to manage pain effectively, they could serve as a starting point for engineering more useful variants. There is likely sufficient incentive to develop alterative pain killers that could replace opioids, given that opioids carry the risk of ...
Original Article: Opioid Painkillers Could Be Replaced by Cancer DrugsNEXT ARTICLE
An anesthesiologist (US English) or anaesthetist (British English) is a physician trained in anesthesia and perioperative medicine. Anesthesiologists are physicians who provide medical care to patients in a wide variety of (usually acute) situations. ...
Pain is a feeling (sharp or dull) triggered in the nervous system which can be transient or constant. Pain can be specific to one area of the body eg back, abdomen or chest or more general all over the body eg muscles ache from the flu. Without pain ...
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...