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In the late 1980’s, an advertising campaign for Crest toothpaste pitted a team of toothbrush-toting superheroes against the dreaded “Cavity Creeps,” who sought to destroy the peaceful, dentally entwined city of Toothopolis. In actuality, the evil cavity creeps are bacterial species that are capable of creating sticky biofilms that allow them to be glued to the surface of teeth, eating away the enamel. Now, University of Alabama at Birmingham (UAB) investigators have created a small molecule that prevents or impedes tooth cavities in rats. Findings from the study were published recently in Scientific Reports in an article entitled “ Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence .” "Our compound is drug-like, non-bactericidal, easy to synthesize, and exhibits very potent efficacy in vivo ," the authors wrote. It is "an excellent candidate that can be developed into therapeutic drugs that prevent and treat dental caries." The ...
Original Article: Small-Molecule Compound Prevents Tooth DecayNEXT ARTICLE
Dentistry is the study, management and treatment of diseases and conditions affecting the mouth, jaw, teeth and their supporting tissues (Oxford Medical Dictionary) The work of a dentist ranges from regular patient check-up to orthodontics and surgery....
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...