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Stem Cell Injections Rejuvenate Ageing Rat Hearts

06:11 EDT 14 Aug 2017 | Genetic Engineering News

Researchers at the Cedars-Sinai Heart Institute have shown that injecting cardiac stem cell from young rats into the hearts of old rats can help to reverse the natural cardiac ageing process. Results from the studies, led by Eduardo Marbán, M.D., Ph.D., director of the Cedars-Sinai Heart Institute, suggest that similar treatments might one day be used to prevent age-related heart function decline and cardiovascular disease in humans. The Cedars-Sinai studies are reported in the European Heart Journal, in a paper entitled, “Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats.” As we get older the likelihood of developing cardiovascular disease increases. Cell senescence underpins the cardiac ageing process, and this is characterized by the shortening of telomeres, the end caps on our chromosomes. Telomere shortening is associated with heart dysfunction and hypertrophy, impaired cardiomyocyte proliferation, interstitial fibrosis and reduced regenerative capacity. Dr. Marbán’s team completed ...

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