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Semaglutide outperforms dulaglutide on HbA1c, weight-loss reduction in type 2 diabetes

12:16 EDT 17 Aug 2017 | Healio

Adults with type 2 diabetes assigned the once-weekly GLP-1 receptor agonist semaglutide in addition to metformin therapy experienced a greater reduction in HbA1c and body weight after 40 weeks compared with those assigned once-weekly dulaglutide and metformin, Novo Nordisk announced in a press release.Results from the SUSTAIN 7 trial demonstrated that patients assigned 0.5 mg weekly semaglutide (Novo Nordisk) saw an HbA1c reduction of 1.5% over 40 weeks vs. a 1.1% reduction for those assigned 0.75 mg weekly dulaglutide (Trulicity, Eli Lilly), from a mean baseline HbA1c of 8.2%. Patients assigned 1 mg semaglutide saw a 1.8% HbA1c reduction vs. a 1.4% reduction for those assigned 1.5 mg dulaglutide. Additionally, more patients achieved at least 5% body-weight loss at 40 weeks when assigned 0.5 mg semaglutide vs. 0.75 dulaglutide (44% vs. 23%), with a greater difference for those assigned 1 mg semaglutide vs. 1.5 mg dulaglutide (63% vs. 30%).

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