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Immunotherapy, Nanotech Combine to Kill Cancer Cells More Effectively

05:00 EDT 18 Aug 2017 | Genetic Engineering News

Scientists at Duke University say they have combined a cancer immunotherapeutic with nanotechnology to improve the efficacy of both therapies in a mouse study. They published their work, "Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers," in Scientific Reports . The new approach also attacked satellite tumors and distant cancerous cells, leading to two mice being cured of the disease and one being vaccinated against it. “Using a combination of immune-checkpoint inhibition and plasmonic gold nanostar (GNS)-mediated photothermal therapy, we were able to achieve complete eradication of primary treated tumors and distant untreated tumors in some mice implanted with the MB49 bladder cancer cells,” wrote the investigators. “Delayed rechallenge with MB49 cancer cells injection in mice that appeared cured by SYMPHONY did not lead to new tumor formation after 60 days observation, indicating that SYMPHONY treatment induced effective long-lasting immunity against MB49 ...

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