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Fatty liver can cause damage to other organs via crosstalk

01:48 EDT 21 Aug 2017 | Medical Xpress

Nonalcoholic fatty liver disease is increasingly common. Approximately every third adult in industrialized countries has a morbidly fatty liver. This not only increases the risk of chronic liver diseases such as liver cirrhosis and liver cancer, but also the risk of type 2 diabetes and cardiovascular diseases. The cause for this is the altered secretion behavior of the fatty liver. It increasingly produces glucose, and unfavorable fats and proteins such as the hepatokine fetuin-A, all of which it releases into the bloodstream. Thus, the secreted substances of the fatty liver enter other organs and trigger further reactions. However, researchers did not know the effects of this "organ crosstalk," which organs are most affected, or what damage is caused by the hepatokine fetuin-A.

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