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AstraZeneca, Ethris Collaborate to Develop mRNA-based Respiratory Disease Therapies

03:56 EDT 21 Aug 2017 | Genetic Engineering News

AstraZeneca and its biologics operation MedImmune negotiated a five year strategic research collaboration with mRNA therapeutics firm Ethris, focused on developing stabilized, non-immunogenic modified RNA therapies for respiratory diseases. The partnership will exploit Ethris’ proprietary Stabilized Non-Immunogenic mRNA (SNIM®RNA) technology, which engineers chemical modifications in RNA molecules  to overcome their innate instability and immunogenicity. Through the agreement Ethris will work exclusively with AstraZeneca and its MedImmune, and Innovative Medicines (IMED) units to develop multiple targets for evaluation against asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Ethris will receive a €25 million upfront payment plus  research funding. The firm is also eligible to earn potential R&D milestones and sales-related royalties. AstraZeneca and MedImmune retain the option to exclusively license each target within the collaboration, upon completion of the agreed research plan.  “This collaboration validates Ethris’ leading position in development and delivery of mRNA therapies for the ...

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