Proteins Mapped in Different Mitochondrial Subcompartments for First Time

04:35 EDT 21 Aug 2017 | Genetic Engineering News

A scientific team in Europe says it has mapped the proteins in the different subcompartments of mitochondria for the first time. The researchers, led by Chris Meisinger, Dr. Red. Nat., and Nora Vögtle Dr. Red. Nat., at the University of Freiburg, along with collaborators from the Leibniz Institute for Analytical Sciences (ISAS) in Dortmund, published their study (“Landscape of submitochondrial protein distribution”) in Nature Communications. “The mitochondrial proteome comprises ~1000 (yeast)–1500 (human) different proteins, which are distributed into four different subcompartments. The sublocalization of these proteins within the organelle in most cases remains poorly defined,” write the investigators. “Here we describe an integrated approach combining stable isotope labeling, various protein enrichment and extraction strategies and quantitative mass spectrometry to produce a quantitative map of submitochondrial protein distribution in S. cerevisiae . This quantitative landscape enables a proteome-wide classification of 986 proteins into soluble, peripheral, and integral mitochondrial ...

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