FDA Approves First Fixed-Dose Combo Treatment for Hyperuricemia in Gout

06:37 EDT 21 Aug 2017 | Genetic Engineering News

The FDA has approved the first fixed-dose combination treatment designed to address in a single pill both causes of hyperuricemia in gout, overproduction and underexcretion of serum uric acid. Ironwood Pharmaceuticals will market Duzallo® (lesinurad and allopurinol), which is indicated as a once-daily oral treatment for hyperuricemia associated with gout in patients who have not achieved target serum uric acid (sUA) levels with a medically appropriate daily dose of allopurinol alone. Allopurinol is a xanthine oxidase inhibitor (XOI) whose action differs from that of uricosuric agents such as lesinurad. Allopurinol is designed to reduce the production of uric acid (UA); while lesinurad is designed to increase renal excretion of UA by selectively inhibiting the action of URAT1, the UA transporter responsible for most renal UA reabsorption. Duzallo will be available in dosages that combine 200 mg of lesinurad with 300 mg of allopurinol, as well as ...

Original Article: FDA Approves First Fixed-Dose Combo Treatment for Hyperuricemia in Gout


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