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Searching for the 'signature' causes of BRCAness in breast cancer

20:00 EDT 20 Aug 2017 | AAAS

(Broad Institute of MIT and Harvard) Breast cancer cells with defects in the DNA damage repair-genes BRCA1 and BRCA2 have a mutational signature known in cancer genomics as 'Signature 3.' But not all breast tumor cells exhibiting Signature 3 have BRCA1 or BRCA2 mutations. Therefore, some consider Signature 3 a biomarker for 'BRCAness,' a sign of a breakdown in BRCA-related DNA repair in general and not BRCA damage in particular.

Original Article: Searching for the 'signature' causes of BRCAness in breast cancer

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