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Researchers identify key compounds to resolve abnormal vascular growth in AMD

11:00 EDT 21 Aug 2017 | Medical Xpress

A compound of specific bioactive products from a major family of enzymes reduced the severity of age-related macular degeneration (AMD) in a preclinical model, according to a new study led by Massachusetts Eye and Ear researchers. The report, published online in the Proceedings of the National Academy of Sciences, suggests that it may be possible to prevent the vision loss resulting from disease-causing angiogenesis and inflammation observed in wet AMD by increasing the expression of specific bioactive lipid metabolites in the retina. The research demonstrates that these bioactive lipids have the ability to regulate inflammatory immune cells in the retina, key regulators of the angiogenic process in this disease. Given this, these molecules show promising therapeutic potential not only for AMD, but also for other major conditions that involve angiogenesis and inflammation, such as cardiovascular disease and cancer.

Original Article: Researchers identify key compounds to resolve abnormal vascular growth in AMD

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