Physicians fine-tune use of diabetes drugs after recent CV safety results

08:50 EDT 21 Aug 2017 | Healio

In 2008, the FDA challenged developers of new diabetes drugs to prove that these agents do not increase cardiovascular risk. Results from those studies are now coming in, and beyond demonstrating safety, several are suggesting that drug classes developed over the past decade can reduce overall cardiovascular mortality and mitigate the heart failure and kidney disease that often result from diabetes.Last year, Endocrine Today assembled a distinguished panel of experts to discuss the topic of CV effects of diabetes medications and what these effects might mean for treating patients (see “Beyond safety, diabetes drugs offer CV benefits” in the August 2016 issue). Since then, findings have been published from key SGLT2 inhibitor studies, including CANVAS and CVD-REAL, that lend evidence to a claim for a class effect with these agents, and from the LEADER trial demonstrating a similar CV benefit from a GLP-1 receptor agonist. Based on LEADER results, an FDA advisory panel in June voted in favor of an expanded indication for liraglutide (Victoza, Novo Nordisk), supporting language in the prescribing information that the drug can reduce CV risk in patients with type 2 diabetes. Similar language was added to the label for empagliflozin (Jardiance, Boehringer Ingelheim) last summer.

Original Article: Physicians fine-tune use of diabetes drugs after recent CV safety results


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