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Retaining one normal BRCA gene in breast, ovarian cancers influences patient survival

01:00 EDT 22 Aug 2017 | Medical Xpress

Determining which cancer patients are likely to be resistant to initial treatment is a major research effort of oncologists and laboratory scientists. Now, ascertaining who might fall into that category may become a little easier for physicians taking care of people with BRCA1/2 mutations. Researchers in the Perelman School of Medicine at the University of Pennsylvania found a relationship between the genetics of tumors with germline BRCA1/2 mutations and whether the tumor retains the normal copy of the BRCA1/2 gene, and risk for primary resistance to a common chemotherapy that works by destroying cancer cells' DNA. The team published their study this week in Nature Communications.

Original Article: Retaining one normal BRCA gene in breast, ovarian cancers influences patient survival

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