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Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists

08:13 EDT 22 Aug 2017 | Nature Publishing

PCSK9 binds to and promotes degradation of LDLR, thus regulating serum levels of LDL. An accessible groove in PCSK9, adjacent to the LDLR-binding site, can be targeted by peptides that disrupt the LDLR interaction.

Original Article: Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists

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