Lilly to Use Topas Platform in Immunology Collaboration

05:27 EDT 22 Aug 2017 | Genetic Engineering News

Eli Lilly will use Topas Therapeutics’ antigen-specific tolerance induction platform to develop new treatments, with an initial focus on external antigens believed to induce inflammation and/or autoimmune disease, Topas said today. The companies have signed a multi-year research and option agreement whose value was not disclosed. Topas did say, however, that it will receive from Lilly R&D funding and payments tied to unspecified “future success” of compounds to be in-licensed by Lilly. The pharma giant has been granted an option for all candidates produced under the collaboration for in-licensing and further development, while Topas has agreed to conduct pre-clinical proof-of-principle studies with Lilly to generate the drug candidates. Topas says its platform is designed to induce antigen-specific immune tolerance by harnessing the liver's natural immunology capabilities. Through the platform, peptide-loaded nanoparticles are selectively targeted towards liver sinusoidal endothelial cells (LSECs), where tolerance against bloodborne antigens is ...

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