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The exponential rise in antibiotic resistant microbes is a major public health threat worldwide. Moreover, with approval times for new antibiotics taking more than a decade in most cases, finding a viable treatment among previously approved compounds is imperative to stem the drug-resistant tide. Now, investigators at the University of Buffalo (UB) have encouraging new data on a trio of antibiotics that when used in concert together, are capable of eradicating deadly E. coli carrying the mcr-1 and ndm-5 genes—making the bacterium immune to last-resort antibiotics. Findings from the new study were published recently in mBio through an article entitled “ Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and blaNDM-5: Preparation for a Postantibiotic Era .” "The threat of gram-negative bacteria, including E. coli carrying mcr-1, is worrisome," remarked lead study investigator Zackery Bulman, Pharm.D., who is currently an assistant professor at the University of Illinois ...
Original Article: Killing Resistant Superbugs with Antibiotic TriumvirateNEXT ARTICLE
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