Macular Degeneration May Be Suppressed by Lipid Signaling Molecules

07:05 EDT 22 Aug 2017 | Genetic Engineering News

Bioactive metabolites derived from the cytochrome P450 (CYP) pathway have been shown to resolve the abnormal vascular growth associated with age-related macular degeneration (AMD). These metabolites, which act as second messengers, can regulate the expression of leukocyte adhesion molecules, changing how immune cells are recruited to areas of disease and injury and getting around the link between inflammation and choroidal neovascularization (CNV). When CNV is curbed, the leaking and rupture of these abnormal blood vessels in the retina is reduced, protecting against retinal detachment. To study the role of CYP pathway–derived lipid metabolites in regulating neovascular disease, scientists based at the Massachusetts Eye and Ear Infirmary used transgenic mice with altered CYP lipid biosynthetic pathways in a mouse model of laser-induced CNV. This preclinical model allowed the scientists to discover that the CYP-derived lipid metabolites epoxydocosapentaenoic acids (EDPs) and epoxyeicosatetraenoic acids (EEQs) are vital in dampening CNV severity. ...

Original Article: Macular Degeneration May Be Suppressed by Lipid Signaling Molecules


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