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Microtubule nucleation: beyond the template

09:54 EDT 23 Aug 2017 | Nature Publishing

Assembly of the microtubule nucleus is energetically unfavourable and, in vivo, microtubule nucleation requires support, such as a stable template, to stabilize the initial weak interactions between tubulin dimers. Microtubules can also be nucleated in the absence of a template by certain microtubule-associated proteins, which stabilize the nascent nucleation intermediates.

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