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[Comment] ACT IV: the final act for rindopepimut?

13:46 EDT 23 Aug 2017 | The Lancet

Glioblastoma remains an almost universally fatal cancer with few recent therapeutic advances. The gene encoding EGFR is the most frequently amplified gene in glioblastoma, with roughly 40% of primary glioblastomas showing EGFR amplification.1 Of these EGFR-amplified glioblastomas, 20–50% are characterised by a truncated gene resulting in the expression of mutated EGFRvIII, which is constitutively active. Activation of the EGFR pathway promotes several downstream pathways with oncogenic potential such as cellular proliferation and invasiveness.

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