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Test reveals potential treatments for disorders involving MeCP2

11:07 EDT 23 Aug 2017 | Medical Xpress

Having twice the normal amount of the protein MeCP2, a condition called MECP2 duplication syndrome, causes severe progressive neuropsychiatric disorders that include intellectual disability, autism spectrum disorders, motor dysfunction and other medical complications. In animal models, normalization of MeCP2 levels has largely reversed the neurological problems, opening the possibility that a similar approach might lead to treatments for patients with these conditions. In a paper published in Science Translational Medicine, a team of researchers from Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Stanford University School of Medicine and the University of California, San Francisco has developed a strategy that allows them to identify potential treatments that would restore altered levels of MeCP2.

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