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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

08:01 EDT 24 Aug 2017 | Nature Publishing

Paz Polak, Jaegil Kim, Lior Z. Braunstein and colleagues have identified patterns of genome-wide mutation in certain breast cancers that can be used to identify those with DNA-repair deficiencies that make the tumor more likely to respond to therapies based on PARP inhibitors or platinum. In contrast, oncogenic mutations in several other DNA-repair genes do not generate these patterns.

Original Article: A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

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