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A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF

08:01 EDT 24 Aug 2017 | Nature Publishing

Kevin Brown and colleagues functionally characterize a melanoma risk locus encompassing PARP1, correlating the risk genotype to PARP1 gene expression levels in melanoma cells. They identify an intronic gene-regulatory variant in PARP1 and find that PARP1 can promote cell proliferation and rescue oncogene-induced senescence, likely through MITF.

Original Article: A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF

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