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PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK–ERK signaling

08:01 EDT 24 Aug 2017 | Nature Publishing

Ernesto Guccione and colleagues report that the transcription factor PRDM15 regulates naive pluripotency in mouse embryos and embryonic stem cells and in derivation of mouse and human iPSCs. They further show that PRDM15 promotes WNT signaling and inhibits MAPK–ERK signaling by directly regulating the expression of R-spondin1 and Sprouty1, respectively.

Original Article: PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK–ERK signaling

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