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Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast

08:01 EDT 24 Aug 2017 | Nature Publishing

Frank Uhlmann and colleagues use chromosome conformation capture (Hi-C) to study mitotic chromosome condensation in the fission yeast Schizosaccharomyces pombe, reporting that small chromatin domains in interphase are replaced by fewer and larger domains in mitosis. They show that condensin sets up longer-range DNA interactions that compact and individualize chromosomes while also restraining local chromatin contacts.

Original Article: Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast

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Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...