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Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries

08:01 EDT 24 Aug 2017 | Nature Publishing

Isabelle Janoueix-Lerosey, Valentina Boeva and colleagues analyze the super-enhancer landscape of 25 neuroblastoma cell lines to define core regulatory circuits controlling gene expression programs. They find and functionally characterize two types of cell identity that contribute to the tumor heterogeneity of neuroblastoma.

Original Article: Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries

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