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Exercise Sensor Protein Points to Drugs That Could Enhance Exercise Benefits

06:46 EDT 24 Aug 2017 | Genetic Engineering News

The body, we know, responds to exercise, which suggests that at some level, the body “knows” if it is exercising. Now, the body isn’t clairvoyant. It responds to exercise via physical mechanisms—and mechanisms can be hacked. Imagine: If the body could be tricked into believing it is active, even if it is sedentary, perhaps it could derive more of the health benefits of exercise. Not so much pain. More gain. While exploring this possibility, scientists based at Leeds University identified a key biomolecular mechanism by which exercise is sensed. These scientists have found that a protein called Piezo1 in the lining of blood vessels is able to detect a change in blood flow during exercise. Piezo1, the scientists asserted, is an “exercise sensor.” They detailed its function in mouse studies. They also indicated that Piezo1 is also found in humans, which suggests that this and other exercise ...

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