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[Comment] Convergence of carbapenem-resistance and hypervirulence in

19:55 EDT 29 Aug 2017 | The Lancet

Klebsiella pneumoniae, first described in 1882, remains a common cause of community-acquired and hospital-acquired infections; but strikingly, the past three decades have witnessed the emergence of two largely non-overlapping K pneumoniae populations: one multidrug resistant (MDR) and one hypervirulent. These strains belong primarily to a few major clonal groups (CGs), such as the K pneumoniae carbapenemase (KPC)-producing CG258 strains, which cause about 50% mortality in high-risk patients admitted to hospitals; and CG23 strains, which are associated with community-acquired pyogenic liver abscess.

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